What autoimmune disease causes sores on the scalp
What autoimmune disease causes sores on the scalp Autoimmune diseases are conditions where the immune system mistakenly attacks the body’s own tissues, leading to a wide array of symptoms and complications. One particular concern for many individuals is the development of sores or lesions on the scalp, which can be both painful and distressing. Several autoimmune disorders are known to cause scalp sores, but understanding the most common ones, their symptoms, and treatment options can help those affected seek appropriate medical care.
One prominent autoimmune disease associated with scalp sores is Lupus erythematosus, especially the discoid form. Discoid lupus primarily affects the skin, leading to round, disc-shaped, scaly patches that often develop on the scalp. These patches may cause hair loss (scarring alopecia) and can leave behind permanent scars if untreated. The lesions are usually erythematous (red) and may be accompanied by inflammation, crusting, and ulceration, which can resemble sores. Lupus-related scalp sores occur because the immune system targets skin components, resulting in tissue inflammation and damage.
Another significant autoimmune condition linked with scalp lesions is pemphigus, particularly pemphigus vulgaris. This rare but severe disease causes blistering and erosions of the skin and mucous membranes, including the scalp. The blisters may rupture, leaving painful sores or erosions on the scalp that can be slow to heal. Pemphigus involves autoantibodies attacking the desmosomes—structures that hold skin cells together—resulting in loss of cell adhesion and blister formation.
Psoriasis, although primarily considered an immune-mediated skin condition rather than a classic autoimmune disease, can also cause scalp sores. The variant called scalp psoriasis results in thick, silvery scales, redness, and sometimes painful or itchy lesions that can resemble sores. These lesions are due to an overactive immune response that accelerates skin cell turnover, leading to plaque formation. When the plaques crack or become inflamed, they can ulcerate or cause sores.

Alopecia areata, though mainly characterized by patchy hair loss, can sometimes be associated with scalp inflammation that causes sores or erythema. In cases where the immune system targets hair follicles, inflammation can lead to scalp discomfort and, in some instances, secondary infections or ulcerations.
Diagnosis of autoimmune-related scalp sores involves a combination of clinical examination, patient history, blood tests for specific autoantibodies, skin biopsies, and sometimes direct immunofluorescence studies. Proper diagnosis is essential since treatment varies widely depending on the underlying condition, ranging from topical steroids and immunosuppressants to more advanced therapies like biologic agents.
Treating autoimmune scalp sores often focuses on controlling immune system activity to reduce inflammation and prevent further tissue damage. For lupus, systemic medications such as hydroxychloroquine may be prescribed. Pemphigus often requires high doses of corticosteroids and immunosuppressants. Psoriasis management includes topical treatments, phototherapy, and systemic agents for severe cases. Early diagnosis and intervention can significantly improve outcomes and prevent permanent scarring or hair loss.
In conclusion, several autoimmune diseases—including lupus erythematosus, pemphigus, psoriasis, and alopecia areata—can cause sores on the scalp. Recognizing the signs and understanding the underlying mechanisms are vital steps toward effective treatment and relief. If you notice persistent sores, lesions, or hair loss on your scalp, consulting a healthcare professional promptly is essential for accurate diagnosis and appropriate care.









