What autoimmune disease causes neck and shoulder pain
What autoimmune disease causes neck and shoulder pain Autoimmune diseases can be complex and varied, often affecting multiple parts of the body simultaneously. One common symptom that many autoimmune conditions share is pain, particularly in the neck and shoulder regions. Understanding which autoimmune diseases cause neck and shoulder pain can be crucial for accurate diagnosis and effective treatment.
One of the most notable autoimmune diseases associated with neck and shoulder pain is rheumatoid arthritis (RA). RA primarily targets the joints, leading to inflammation, swelling, and pain. When RA affects the cervical spine—the neck area—it can cause significant discomfort, stiffness, and limited mobility. The inflammation may involve the atlantoaxial joint (between the first and second neck vertebrae), resulting in instability or compression that can radiate pain into the shoulders and upper back. Patients often report persistent neck stiffness, especially in the mornings, which may worsen with activity.
Another autoimmune condition to consider is polymyalgia rheumatica (PMR). This disorder predominantly affects older adults and is characterized by muscle pain and stiffness, especially in the shoulders and neck. The pain from PMR is typically symmetrical and can be severe, often making it difficult to raise the arms or turn the head comfortably. PMR is closely linked with elevated inflammatory markers in the blood, and timely treatment with corticosteroids usually leads to rapid symptom relief.
Systemic lupus erythematosus (SLE), a multisystem autoimmune disease, can also involve musculoskeletal symptoms, including neck and shoulder pain. While joint pain is common in SLE, inflammation of the surrounding tissues and muscles can cause localized discomfort in these regions. The pain may be associated with other systemic symptoms, such as fatigue, skin rashes, and fever, underscoring the importance of comprehensive evaluation.

Sjögren’s syndrome, primarily known for causing dry eyes and mouth, can also involve the musculoskeletal system. Some patients experience neck and shoulder pain due to inflammation of muscles, joints, or surrounding tissues. This pain often coexists with other symptoms of the syndrome and may be mistaken for other musculoskeletal conditions if not properly diagnosed.
Another autoimmune disease that can lead to neck and shoulder pain is ankylosing spondylitis, a form of inflammatory arthritis primarily affecting the spine. Although it usually starts in the lower back, the disease can progress to involve the cervical spine, causing stiffness, pain, and decreased mobility in the neck and shoulders. The pain tends to be worse in the mornings and improves with activity, but over time, it can lead to significant deformity if untreated.
In all these conditions, the common denominator is inflammation—an immune system overreaction attacking the body’s own tissues. Proper diagnosis often involves blood tests, imaging studies, and clinical evaluation. Treatment typically focuses on reducing inflammation through medications such as NSAIDs, corticosteroids, or disease-modifying antirheumatic drugs (DMARDs), alongside physical therapy to maintain mobility.
Understanding the connection between autoimmune diseases and neck or shoulder pain is vital for patients experiencing persistent discomfort. Early diagnosis and management can significantly improve quality of life, prevent complications, and address the underlying immune dysfunction.









