What autoimmune disease causes breathing problems
What autoimmune disease causes breathing problems Autoimmune diseases occur when the body’s immune system mistakenly targets its own tissues, leading to chronic inflammation and tissue damage. Among the many health challenges posed by autoimmune conditions, breathing problems can be particularly severe and alarming. Several autoimmune diseases are known to directly or indirectly cause respiratory issues, making awareness and early diagnosis vital for effective management.
One of the most prominent autoimmune diseases associated with breathing difficulties is Systemic Lupus Erythematosus (SLE). Lupus is a systemic condition that can affect multiple organs, including the lungs. Pulmonary involvement in lupus may manifest as pleuritis (inflammation of the lining around the lungs), which causes sharp chest pain and difficulty breathing. In more severe cases, lupus can lead to pulmonary hypertension, interstitial lung disease, or even alveolar hemorrhage, all of which impair lung function and cause persistent breathing problems.
Another key autoimmune disease affecting respiration is Rheumatoid Arthritis (RA). While primarily known for joint inflammation, RA can also involve the lungs. Rheumatoid nodules can develop in lung tissue, and the disease can cause a form of interstitial lung disease characterized by scarring of the lung tissue. This scarring diminishes lung capacity and elasticity, leading to shortness of breath, especially during exertion. Additionally, RA-associated pleuritis can cause chest pain and breathing difficulties.
Sjögren’s Syndrome is an autoimmune disorder that mainly targets moisture-producing glands, leading to dry mouth and dry eyes. However, it can also involve the lungs, causing inflammation of the airways (bronchitis) or the lung tissue itself. Patients with Sjögren’s may experience a chronic cough, shortness of breath, or wheezing due to these pulmonary involvements.
Hashimoto’s Thyroiditis, another autoimmune condition affecting the thyroid, can sometimes contribute to breathing problems, especially if it leads to hypothyroidism. Severe hypothyroidism can cause a condition called myxedema, resulting in swelling of tissues, including the tongue and throat, which can obstruct the airway and cause breathing difficulties. Though less common, this highlights how autoimmune diseases can have indirect effects on respiration.

Multiple Sclerosis (MS), although primarily a neurological autoimmune disorder, can also cause respiratory issues. MS can weaken the muscles involved in breathing or impair the neural pathways controlling respiratory functions. In advanced stages, this can lead to respiratory muscle weakness, resulting in decreased ventilatory capacity and increased risk of respiratory failure.
Finally, Vasculitis, a group of autoimmune disorders characterized by inflammation of blood vessels, can involve lung tissue and blood vessels within the lungs. Conditions like granulomatosis with polyangiitis (GPA, formerly Wegener’s granulomatosis) can cause bleeding, granuloma formation, and tissue destruction in the lungs, leading to cough, hemoptysis (coughing up blood), and difficulty breathing.
Overall, autoimmune diseases are complex and can affect the respiratory system in various ways. Recognizing the symptoms early, such as persistent cough, shortness of breath, chest pain, or wheezing, is crucial for diagnosis and treatment. Managing these diseases often involves immunosuppressive therapies to reduce inflammation and prevent tissue damage, but addressing respiratory symptoms may also require supplemental oxygen, pulmonary rehabilitation, or other supportive measures.
Understanding the link between autoimmune diseases and breathing problems underscores the importance of interdisciplinary care involving rheumatologists, pulmonologists, and primary care providers. Early intervention can significantly improve quality of life and reduce the risk of severe respiratory complications.









