Cpt code for immunotherapy injections
Cpt code for immunotherapy injections Immunotherapy has emerged as a groundbreaking approach in the treatment of various allergic conditions and certain cancers. Central to the administration of immunotherapy is the use of injections designed to desensitize or stimulate the immune system, which are meticulously coded for billing and documentation purposes using specific CPT (Current Procedural Terminology) codes. These codes ensure accurate reporting, proper reimbursement, and standardized communication among healthcare providers.
CPT codes for immunotherapy injections primarily fall under the category of allergy and immunology procedures. For allergy immunotherapy, the codes generally start with 95115 through 95117, which cover the serial administration of allergen extracts. These codes are used when a patient receives injections of allergen extracts as part of allergy desensitization. For instance, CPT 95115 is used for the initial allergy immunotherapy, which includes the extraction and administration of allergen doses, while subsequent codes like 95117 pertain to subsequent injections.
In addition, when considering immunotherapy for cancer treatment, the coding becomes more specific to the type of therapy administered. For example, immune checkpoint inhibitors such as pembrolizumab (Keytruda) or nivolumab (Opdivo) are billed under different codes that reflect their administration rather than the drug itself. These are often reported using the “administration” CPT codes, which are 96365 for intravenous infusion, initial, and 96366 for subsequent, or the codes for subcutaneous injections like 96372. The choice of code depends on the route and method of administration, as well as the setting of care.
It’s also important to note that billing for immunotherapy injections involves consideration of various factors such as the number of injections, whether the injections are allergy extracts or biologic agents, and the complexity of the procedure. For instance, administering a series of allergy shots may involve multiple visits, each documented

with the appropriate CPT code. Conversely, immunotherapy for cancer may be a more complex procedure, requiring additional codes for monitoring and management.
Healthcare providers must remain current with the American Medical Association’s CPT code updates, as codes for immunotherapy procedures can change annually. Proper documentation of the procedure details—such as the type of immunotherapy, method, and setting—is essential for correct coding and reimbursement. Furthermore, understanding payer-specific policies is crucial, as some insurers may have specific requirements for covering immunotherapy treatments.
In summary, CPT coding for immunotherapy injections is quite diverse, reflecting the broad range of therapies from allergy desensitization to cancer immunotherapy. Accurate coding ensures that providers are correctly reimbursed, and patients receive appropriate treatment documentation. Staying informed about updates and nuances in CPT coding is vital for healthcare professionals involved in administering and billing for these innovative therapies.









